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The Role of Dietary Components in Leptin Resistance

A greater proportion of PDAC-associated diabetes in NOD individuals occur within 0 to 12, 12 to 24, and 24 to 36 months prior to PDAC diagnosis, while similar proportions of PDAC-associated diabetes and control populations occur past 36 months, thus establishing the criticality of diabetes presentation 3 years before PDAC as a window of opportunity for early detection ( Figure 4A ) (91)

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As the liver plays key roles in inflammatory responses, substance metabolism, immune regulation, and excretion [11], it acts both as a target of injury and an "amplifier" of systemic inflammation in the process of host response failure and multi-organ damage