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These toxins usually come from prescription medications for pain relief, antibiotics, and contraceptive pills, and also from processed foods, alcoholism, smoking, and environmental pollution

it can be found in trace amounts in our environment and accumulate in our body over time

Promoting this phenotypic conversion could theoretically resolve the maladaptive neuroinflammatory environment implicated in tinnitus while preserving the beneficial, homeostatic functions of microglia

Additionally, PAHs, such as benzo[a]pyrene, are oxidized in the liver by CYP1A1 and CYP1B1 to form epoxides, which are subsequently hydrolyzed by epoxide hydrolase (EH) into highly reactive diol epoxides (e.g., BPDE), thereby driving the molecular mechanisms of bladder cancer (Thier et al., 2003