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The ginsenoside fraction Rb1 can balance Th1 and Th2 cells differentiation and ginsenosides Rd, and Re can improve both the Th1- and Th2-related cytokine release (Rivera et al., 2005

These targets are pharmacologically tractable (small molecules, nutraceuticals, or biologics) and amenable to gene or nanoparticle approaches demonstrated in preclinical studies

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Although oligodendrocytes are mainly responsible for transferrin expression and secretion, they take non-transferrin-bound iron in the form of ferritin via the Tim-2 receptor