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K.SchwarzE.GuestP

This approach not only aims to inhibit aberrant vessel growth but also to restore the functionality of existing vessels, which is crucial for effective drug delivery and overall tumor control (77)

The involvement of medicinal chemists will also help delineate the impacts of different structural changes, such as different terminal linkages with GSH ( C -terminal, S -terminal, and N -terminal), on binding selectivity and efficiency, and establish structure-activity relationships (SAR) for the development of glutathione transporter-based brain targeting ligands