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This finding brought together the antioxidant property of UA with the consistently topical concept of oxidative stress as a critical factor in the pathogenesis of PD

[DOI] [PubMed] [Google Scholar] 12.Buhl R, Jaffe HA, Holroyd KJ, Wells FB, Mastrangli A, Cantin A, Saltini C, Cantin AM, Crystal RG

3.1 Overview of targeted signaling pathways of natural products The NPs exhibit therapeutic potential in IPF by modulating key signaling pathways involved in inflammation, myofibroblast activation, oxidative stress, and ECM deposition

Mutations in the HFE gene are the major cause of hereditary hemochromatosis, a genetic disorder characterized by impaired regulation of TfR-mediated iron uptake, leading to excessive iron absorption and iron overload in organs such as the liver, heart, pancreas, and joints, ultimately resulting in tissue damage (Brissot et al., 2018