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Notably, ECs display considerably reduced levels of intercellular adhesion molecules (ICAMs) in comparison to ECs in peripheral organs, thereby imposing stringent limitations on immune cell ingress into the brain tissue [34, 35]

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In addition, the use of mTOR inhibitors can inhibit EMT and the expression of NGF which were promoted by the activation of HGF/c-Met signaling pathway (Supplementary Figs

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