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To view a copy of this license, visit About this article Cite this article Laoukili, J., Constantinides, A., Wassenaar, E.C.E

While pharmacological treatments and phytochemicals could provide symptomatic relief and neuroprotective effects, their efficacy is hindered by poor bioavailability, systemic side effects, and restricted BBB penetration

Three of the men developed a reversible peripheral neuropathy showing abnormal nerve conduction and, in 2 cases, headache, weakness and decreased reflexes in the extremities, incoordination, and a wide-based gait