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429 Subsequent studies found that FtMt overexpression reduced ROS and the contents of unstable iron in cytoplasm and mitochondria

Fatty acids released from adipose tissues during fasting accumulate in various organs predisposing to their impaired function.[5][6] Accumulation of fat in the liver causes steatosis and impairment of ketone body production.[5][6][8] In the heart and skeletal muscles, this abnormal accumulation results in cardiomyopathy and myopathy respectively.[5][6] Heart derives two-thirds of its energy from free fatty acids and this predisposes patients with impaired carnitine metabolism to the development of cardiomyopathy.[6] Additionally, impaired lipid metabolism can affect the electrical rhythm of the heart resulting in arrhythmias.[6] The brain utilizes ketone bodies as an alternate energy source in fasting states

Boullier A, Bird DA, Chang MK, Dennis EA, Friedman P, Gillotre-Taylor K, et al Scavenger receptors, oxidized LDL, and atherosclerosis Ann N Y Acad Sci

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