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Insulin promoting the growth and proliferation of cells is one of the mechanisms underlying increased cancer risk in obese and diabetic patients (119, 120)

Following the established SUPPA2 pipeline 46 (Methods), we assigned relative abundances of the splicing events or transcript isoforms (referred to as proportion spliced-in (PSI) 47 ) for each transcript across all three timepoints, under four different conditions: T-REX (NCBP1-HNEylation) and three controls (DMSO-alone, light-alone or probe-alone treatment)

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Tanaka K, Masaki Y, Tanaka M et al (2014) Exenatide improves hepatic steatosis by enhancing lipid use in adipose tissue in nondiabetic rats