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Additionally, berberine demonstrated strong binding affinity to the allosteric sites of AMP-activated protein kinase (AMPK) - and -subunits, which could contribute to the modulation of inflammatory responses as well (107)

Indeed, in the acute respiratory distress syndrome (ARDS) that are caused by COVID-19, BHB fuels into the tricarboxylic acid (TCA) cycle and cause the T cells to rely on oxidative phosphorylation (OXPHOS) while promoting the synthesis of amino acids that are drained during infection (90)