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Despite their high concentration of catalase, peroxisomes were found to house most components of the pathway (Jimnez et al

In ovarian cancer, the combination of DOX and withaferin A (WFA) produced synergistic anti-tumor effects, significantly reducing tumor growth and angiogenesis in both 3D and xenograft models via ROS generation, DNA damage, autophagy, and apoptosis induction, while concurrently reducing the necessary DOX dosage (146, 147)