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Erastin, one of the earliest discovered ferroptosis inducers, inhibits system Xc - (SLC7A11/SLC3A2), thereby impairing GSH synthesis, leading to ROS accumulation and inducing GBM cell death ( 2+ levels, increased GSH levels, and suppressed expressions of ferroptosis-related proteins such as GPX4, NRF2, and SLC7A11 ( RAS-selective lethal 3 (RSL3) is a known ferroptosis inducer

In addition, batch growth data from literature 48 was used to evaluate model predictions, quantitatively

Liposomal-based: As discussed, this is the gold standard for glutathione absorption

Lamictal, specifically in epileptic adults at 500mg, has been shown to cause ataxia (difficultly walking) in 28%, blurred vision in 25%, diplopia (double vision) in 49%, dizziness in 54%, nausea in 25%, vomiting in 18%, and in some, life-threatening allergic and skin reactions