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De Sanctis MT, Belcaro G, Incandela L, Cesarone MR, Griffin M, Ippolito E, Cacchio M

Negut I, Grumezescu V, Grumezescu AM

Secondary injury refers to spinal cord edema caused by an external force, as well as further damage to the spinal cord caused by spinal cord compression, which may be due to fragmented intervertebral disc tissue, imbalance of gliosis, cytokine release, excessive proliferation of gliocytes, microglia and macrophage accumulation at the injury site, or the formation of astroglial scars, fibrous scars, and syringomyelia (Onyango et al., 2021) (Figure 1)