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Ethics declarations Ethics approval and consent to participate This study was performed in accordance with the regulations of Chongqing Medical University Standing Committee on human biomedical research and animal experiments, and were approved by the Institutional Committee

Later, other studies demonstrated that TanIIA mitigates bleomycin-induced pulmonary fibrosis, myofibroblast activation, collagen deposition, inflammatory cell infiltration and pro-inflammatory cytokine release in murine models (He et al., 2015

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This subsequently causes Ca 2+ translocation, ROS production, and activation of cellular pathways