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Aiming to identify other key genes potentially involved in the impairment of thyroid function, differential expression analysis revealed a set of TFs differentially expressed in Nrf2 KO cells (Fig 6B)

In addition, small molecule inhibitors including SLC7A11 inhibitor HG106 and GCLC inhibitor buthionine sulfoximine (BSO) were introduced to investigate their effects on ROS, GSH levels and cellular viability in VRK2-KO and VRK2-KD cells, and the results were consistent with the above knockdown experiment (Fig

Also, AC undergoes extensive metabolism, including oxidation, glucuronidation, sulfation, and methyl conjugation, yielding a wide range of metabolites

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