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& Beynen, A

Among these complications, acute pain due to vaso-occlusion is the most common reason for emergency department visits of SCD patients (Yusuf et al., 2010

Early identification of these mutations through genetic workups not only supports accurate diagnosis but also allows for prompt and tailored treatments, as summarized in Table II, which compares treatment modalities, their mechanisms, genotype associations, effectiveness and limitations (17,38)