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The analysisof MDR mechanisms shows that the sensitivity of tumor cells to the therapy is dependent on cell context--on the combination of peculiarities of the regulatory pathways connected with the species and tissue lineage of the cell and also with genetic alterations arising in the cells during carcinogenesis and tumor progression

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Allele-specific change of concentration and functional gene dose for the prediction of steady-state serum concentrations of amitriptyline and nortriptyline in CYP2C19 and CYP2D6 extensive and intermediate metabolizers