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doi: 10.1056/NEJMoa1500596

Wang Y, Zhang Y, Wang W, Zhang Y, Dong X, Liu Y

These are called conjugated proteins , and the non-peptide components are referred to as prosthetic groups

The enzyme is complex, with four copper atoms, two or more disulfides, glycosylation, optimal activity at acidic pH (pH 45) and an electron transfer pathway that is strongly interrupted by modest concentrations of hydroxyl anions or halides (for example, NaCl and KCl) in cell culture media 21