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Since then, a considerable amount of NK research has been performed on NK in Japan, Korea, China, and the United States, and these studies confirmed that NK, an alkaline protease of 275 amino acid residues with a molecular weight of approximately 28 kDa, 4 is the most active ingredient of natto and is responsible for many favourable effects on cardiovascular health

Anyhow, the sample size wasnt big

Cyclic vomiting syndrome in adults: clinical features and response to tricyclic antidepressants

A review of more than 4 million metformin patients found testing rates fell from about 40 percent in the early 2000s to roughly 20 percent by 2018 through 2020, in a study led by Bhanja and colleagues