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The value of the combo lies in **mechanistic divergence coupled with vascular convergence**: BPC-157 covers local cytoprotection and the gut-tendon axis, TB-500 covers systemic cell migration and stem-cell mobilization, and both converge on the neoangiogenesis required for deep tissue regeneration

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Leukemia 34:317321 Horenstein A, Quarona V, Toscani D, Costa F, Chillemi A, Pistoia V et al (2016) Adenosine generated in the bone marrow niche through a CD38-mediated pathway correlates with progression of human myeloma

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