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doi: 10.6026/973206300200765 88

Evidence from in vitro and in vivo models of SCA3 highlights significant disturbances in this pathway, particularly the aberrant stimulation of ERK, a member of the MAPK family

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OS extract leads to a reduction in intracellular calcium levels and subsequent relaxation via ion influx inhibition through VOCC, as the nifedipine action, and reduces vasoconstriction caused by phenylephrine, demonstrating its involvement in IP3 and/or ryanodine receptors