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Niacin receptors (HCAR2) on microglia respond to butyrate and other SCFAs, triggering anti-inflammatory signaling [116]

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These sequences are mostly unstructured representing the IDR regions of proteins and initiate the formation of unique condensates where many molecules of -synuclein slowly transform into the beta-pleated structure mediated by transient multivalent interactions

Despite these limitations, non-enzymatic sensors offer unparalleled durability, simplicity, low cost, and long-term stability, making them ideal for continuous monitoring of specific metabolites in ISF