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Despite the availability of multiple chemotherapeutic options, clinical efficacy remains limited due to poor drug solubility, restricted intestinal absorption, rapid systemic clearance, and multidrug resistance

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Nevertheless, knockout of p53 or p21 paradoxically accelerates gastrointestinal damage and death, indicating that p53 may have a bidirectional effect in radiation-induced injury (198)

Jin believed that proteins that mimic these cytokine receptors could help combat cytokine storms, which can be produced by viral or bacterial infections, including HIV and hepatitis