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Shibasaki, Retinal detachment-induced Mller glial cell swelling activates TRPV4 ion channels and triggers photoreceptor death at body temperature

While loop diuretics (high-ceiling diuretics) such as furosemide inhibit the Na + /K + /Cl co-transporter in the ascending loop of Henle, potassium-sparing diuretics (acting in the collecting tubule) such as spironolactone correct K + loss during the Rx with thiazide and loop diuretics

Brouquet A, Overman MJ, Kopetz ES , Maru DM, Loyer EM, Andreou A, Cooper A, Curley SA, Garrett CR, Abdalla EK, Vauthey JN

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