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While vitamin B12 deficiency is rare and most people get enough B12 from their diets, some people may be at greater risk of low B12 levels, including vegetarians and vegans, older adults and people with digestive system conditions, such as Crohn's disease and celiac disease

The study, included only research that followed the randomized, double-blinded, placebo-controlled model of a phase IIb clinical trial in order to keep the highest possible standards of evidence

Why certain patients require more frequent treatment is not understood

"Neuroendocrine control of brown adipose tissue." Neuroendocrinology, 77(1), 1-8