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10.1039/c8mt00224j 41 JiangX.JiS.YuanF.LiT.CuiS.WangW.et al (2023)

atropine, amitriptyline, hyoscamine, and injections of botulinum toxin into the salivary glands) (Giess 2000

We found that expression of GPX4 was reduced after Cys 2 starvation and erastin treatment, further proving that ferroptosis is a primary mechanism of GSH depletion-induced cell death in RPE (Fig

Mitochondrial dysfunction hypothesis Mitochondria, cells energy factories, play a key role in maintaining intracellular calcium homeostasis and signal transduction and provide necessary ATP energy for maintaining normal cell function through the oxidative phosphorylation (OXPHOS) mechanism [43, 44]