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From a translational perspective, OSC-mediated immunomodulationprincipally via Nrf2 activation and NF-B suppressionoffers therapeutic benefit in hyperinflammatory states but may compromise host defense if dosing, duration, or clinical context are not carefully controlled (Fagian et al., 2020

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Oral absorption is considered too unreliable in patients with pernicious anemia or other conditions resulting in malabsorption of vitamin B12

GSH is a promising and clinically feasible drug that promotes fat graft survival by inhibiting ferroptosis via the SLC7A11/GPX4 axis