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Ann Thorac Surg 79(5):1716-23, 2005

Cleavable linkers in antibody-drug conjugates

To test if MS4A15 extensively inhibits ferroptosis, we generated pooled Ms4a15 -overexpressing mouse immortalized fibroblasts ( Ms4a15 OE) [32, 33] and characterized resistance to different ferroptosis inducers (1S,3R)-RSL3 (RSL3), imidazole ketone erastin (IKE), ferroptosis inducer derived from CIL56 (FIN56), and genetic ablation of Gpx4 (Fig