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Acknowledgements We would thank Professor Shuang Wang, Clinician Hui Chen (Department of Pathology, Nanfang Hospital), Dr

Conversely, in specific microenvironments (e.g., the weakly acidic tumor microenvironment or sites of bacterial infection) or in the presence of specific substrates, their POD-like (converting H 2 O 2 to OH under acidic conditions) and OXD-like activities are activated

Its core actions involve: (1) Direct binding to the catalytic domain of matrix MMP-9(Kd = 8.4 nM) and active sites of MMP-1/3, with Ce6-diPEG-curcumin conjugates (200 nM) combined with photodynamic therapy reducing UVB-induced MMP-2 expression by 67% (Thapa Magar et al., 2023