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Int J Mol Sci 2015

Metalloproteinase Balance Wound healing depends on a careful balance between matrix metalloproteinases (MMPs), which break down damaged tissue, and their inhibitors (TIMPs)

Besonders bei erhhter Belastung kann es zu einer schnellen Erschpfung kommen

The early-stage patient fibroblasts showed a significantly higher basal respiration than TDP-43 G376D Asymptomatic fibroblasts, but a much lower spare respiratory capacity, whereas late-stage patient fibroblasts behaved as the TDP-43 G376D Asymptomatic fibroblasts, having similar basal respiration, maximal respiration, and spare respiratory capacity (Fig