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A similar effect of 7,25-DHC was demonstrated on chondrocytes, where caspase-related cell death through extrinsic and intrinsic apoptotic mechanisms was observed [94]

A retrospective study of anemia in 456 dogs (excluding those with acute blood loss anemia) showed that the most frequent causes of anemia were inflammatory disease and cancer-associated anemia (which could be multifactorial in origin and the cohort could have included cases with splenic tumor-related hemoperitoneum), which comprised 62% of the total cases, followed by immune-mediated hemolytic anemia (IMHA, 13% of cases)

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The results from the NutriNet-Sant study (Debras et al., 2022b), which were based on the most specific aspartame exposure assessment, were also thoroughly adjusted for the major confounders, including age, sex, lifestyle, and BMI