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Symptoms can range from mild irritation to severe, activity-limiting pain

Vincent L, Kermani P, Young LM, Cheng J, Zhang F, Shido K, Lam G, Bompais-Vincent H, Zhu Z, Hicklin DJ: Combretastatin A4 phosphate induces rapid regression of tumor neovessels and growth through interference with vascular endothelial-cadherin signaling

They also provide mechanical support to the growing cells by preserving the three-dimensional architecture and mimicking natural tissue structure, however, they have some limitations

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