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discontinue treatment if the patient cannot tolerate this maintenance dose

Hence, the presence of l-alanine in the l-alanyl-l-glutamine dipeptide or in its free form and supplemented in tandem, can spare glutamine metabolism in order for the latter to be used by high-demand tissues under inflammatory and/or highly catabolic situations (Reference Cruzat, Pantaleao and Donato7,Reference Cruzat and Tirapegui32)