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The pKa, which describes the dissociation of the neutral form to the negatively charged form, of sulfadiazine is 6.5 17 , making the dissociation of sulfadiazine relevant in the environment, where even slight pH changes in the vicinity of the pKa will have a major impact on the balance between the neutral and ionized fractions (Fig

Ristoff E, Mayatepek E, Larsson A

Despite its potential significance, some studies have not identified statistically significant differences between PD patients and controls [20], suggesting the need for further validation