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In return, the liver modulates the intestinal microbiota by secreting BAs, immunoglobulin A, and antimicrobial molecules into the intestine 34

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The former is a NAD+ ectohydrolase that breaks down NAD+ to nicotinamide (NAM) and ADP ribose (ADPR), which can then be hydrolyzed to eADO by CD73 and interrupt T cells via the adenosinergic pathway (96)