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As the diversity of use patterns and application methods expanded, exposure pathways and the frequency of relatively high exposure episodes for both people and non-target organisms also increased

Although the impact of vitamin D supplementation on gut microbiota composition remains inconclusive [33], largely due to methodological heterogeneity and limited sample sizes, emerging data suggest that several bacterial taxa, including butyrate-producing species, appear to be positively influenced by vitamin D status [31]

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In agreement, we observed that cellular GSH levels and the ratio of GSH/GSSG were increased in DMF treatment group (Fig