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Constituents: Steroidal Saponins & Lactones: withanolides (mainly A & B) & withanosides I-VII (mainly V), withaferin A & sitoindosides VIIX Alkaloids (withasomine, cuscohygrine and anahygrine) Nutrients & Minerals (iron) Medicinal actions: Adaptogen Anti-inflammatory Antioxidant Anti-rheumatic Cytotoxic (Anti-cancer) Hypoglycemic Hypolipidemic Immunomodulator Nervine Tonic & Relaxant Reproductive Tonic Mechanism of Action & Pharmacology: Potent antioxidant effects may be largely responsible for Withanias diverse pharmacological properties

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Oral pirfenidone in patients with chronic fibrosis resulting from radiotherapy: a pilot study