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In human, Filipe et al

The breakdown of coffee compounds can create reactive intermediates that reduce glutathione

Nat Rev Neurol 14:606617

et al., 2023) the cAMP/PKA/p-CREB pathway was altered in the amygdala alongside neuronal apoptosis (Jiang et al., 2023), and cortical cytokinesincluding IL-1, IL-6, and TNF- were elevated (Wang J