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NNMT is a cytosolic enzyme that is primarily expressed in the liver and catalyzes the transfer of methyl group from the cofactor S-(5-adenosyl)-L-methionine (SAM) to other substrates

Once inside adipocytes and other metabolically active cells, the compound binds to the NNMT active site, preventing the enzyme from converting nicotinamide to 1-MNA

Deeper treatments should be done by a licensed practitioner

Furthermore , it plays a role in addressing neuropathies, which are disorders affecting the peripheral nerves and can cause symptoms like numbness, tingling, and weakness, often seen in conditions like diabetes or alcoholism