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Pathological iron accumulation appears to result from altered expression and function of iron transport proteins at the blood-brain barrier, exacerbated by inflammatory cytokines and oxidative stress that modulate key iron transporters such as transferrin receptor, divalent metal transporter 1, and ferroportin

Godic A, Poljak B, Adamic M, Dahmane R

The optimal dosing and administration of thiamine for the treatment of AD is still being investigated

Doctors also need to be aware that a cherry red spot in the eye could indicate other possible issues, such as an injury to the eye, inflammation around the optic disc, certain genetic disorders, or negative reactions to some drugs