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By integrating paired proteomic analysis with machine learning, we demonstrate that quinoa bioester induces coordinated molecular changes in barrier function, oxidative defense, and protease regulation, providing a foundation for objective assessment of cosmeceutical effects and opening new avenues for evidence-based and unbiased evaluation of skin care formulations

Resorufin fluorescence was determined at 530 nm ex /590 nm em with a Tecan Infinite M200 reader