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(170), transplanting the fecal microbiota of MDD patients into sterile rats led to an increase in fecal SCFA levels when compared to controls and sodium butyrate improved depressed behavior in rats

doi: 10.1016/S0041-0101(97)00074-3

These factors, including substance P, interleukin-1 (IL-1), tumor necrosis factor- (TNF-), and transforming growth factor- (TGF-), bind to their respective receptors on astrocytes, activating downstream signaling pathways that promote astrocyte proliferation, hypertrophy, and adoption of the reactive phenotype (64)