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Apraxia of lid opening in subthalamic nucleus deep brain stimulation for Parkinsons disease-frequency, risk factors and response to treatment

Foresta et al suggested that hypotestosteronemia was related to the reduction of circulating EPCs in young hypogonadotropic hypogonadal men [52], whereas the reduction of EPCs could be reversed by the testosterone replacement through a direct stimulatory effect on the bone marrow [53], and the androgen receptor/VEGF/cyclin A-mediated mechanism may be involved in this process [54]

Conversely, accidental cell death is triggered by unexpected injury stimuli that exceed the cells regulatory capacity, leading to various forms of cell demise such as necroptosis and pyroptosis