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This early finding suggests that it is eliminated from the body fairly rapidly, and probably does not pose too much of a risk of building up to dangerous levels if taken for extended periods nonetheless, more studies in human users will be needed to know for sure, so this should not be considered a definitive finding until more research is done

Vitamin D and actigraphic sleep outcomes in older community-dwelling men: the MrOS sleep study

The key role of histone acetylation in mGlu2 receptor regulation is also strengthened by the findings that chronic treatment with atypical antipsychotics down-regulates the expression of mGlu2 receptors in the mouse and human prefrontal cortex by increasing the binding of HDAC2 to the Grm2 promoter [39]

These high doses, given as a single bolus, may worsen clinical status and are no longer recommended