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Oral citicoline (1,600 mg/day) was given for 60 days followed by 60 days of washout, and the therapeutic cycle was repeated once

10.3389/fcell.2024.1381470 77 WangL.ChenS.PeiW.HuangB.NiuC

Characterization of the human gene for a polypeptide that acts both as the beta subunit of prolyl 4-hydroxylase and as protein disulfide isomerase

Vectorial flow replaces the old free diffusion view, as ROS are generated at membranes or enzyme clusters and then channeled along protein networks, redox relays and contact sites (e.g., MAMs) to reach defined effectors