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Figure 4 Macrophages are the key mediators by which monoclonal antibodies to play a therapeutic role, and antibodies targeting CD38 will also affect macrophage function ( Summary and Prospects CD38 has dual functions, acting as an extracellular enzyme and a surface receptor

Typically, the recommended dose for adults is 1000-5000 mcg of methyl cobalamin injected into a muscle or under the skin once daily or weekly, depending on the severity of the deficiency

Some drugs, such as metformin or proton pump inhibitors, may impair B12 absorption by altering stomach acidity or intestinal function

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