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Patients must be counseled that these compounds support biologic improvement over weeksnot hoursand work best when added to an existing procedure plan rather than used alone

CID data were used for peptide identification, and uptake quantification was performed at the peptide level (as CID results in deuterium scrambling)

Complementary theoretical and experimental studies further suggest that phenotypic mutations, including ribosomal frameshifts and stop-codon readthrough, generate transient proteoforms that can buffer genetic defects, expand functional diversity, and shape long-term protein evolution (Goldsmith and Tawfik, 2009

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