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As expected, overexpression of WT GCLC or its desuccinylation-mimicking mutants (K38R, K126R, K326R or 3KR) in U2OS cells significantly enhanced the cellular GSH levels compared to empty vector control (NC) (Fig

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The antioxidant enzyme system includes superoxide dismutase (SOD), peroxidase (POD), catalase (CAT), ascorbate peroxidase (APX), and glutathione peroxidase (GPX) (Laxa et al., 2019) Non-enzymatic systems include small organic molecules with antioxidant capabilities, such as polyphenols, carotenoids, vitamin C, glutathione, melatonin and polyamines (Hernndez et al., 2012

Conclusion The TB-500 FDA approval status is clear: it is not FDA approved and has no active pathway toward regulatory approval