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Figure 2 NF1, PTEN, and TSC1/TSC2 act as negative regulators of mTOR complex 1 (mTORC1), of which single gene mutations lead to enhanced mTOR activity in the brain in various mouse models (60, 62, 65)

(41) Table 1 Effects of OMWW extracts on normal cells

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Tremendous evidence suggests that the tumor has evolved at least three mechanisms to avoid ferroptosis, such as downregulating PUFA-PL levels and lipid peroxidation, astricting the storage of iron in LIP, and uprising defense systems against ferroptosis