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Rhizoma Dioscoreae Bulbiferae extract, though anti-tumor, downregulates P-gp and MRP2, reducing pirarubicin efflux and increasing its accumulation and cardiotoxicity

In addition, KEGG enrichment of the transcriptome highlighted the enrichment of genes related to IL-17 and TNF- signaling, GO analysis flagged inflammatory-response processes, and GSEA showed that XSJ suppressed the chemokine-binding pathway, collectively revealing broad anti-inflammatory activity at the molecular level

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Polyzos SA, Kountouras J, Goulas A, Duntas L (2020) Selenium and selenoprotein P in nonalcoholic fatty liver disease